Why does isoniazid kill dogs?

Isoniazid is an anti-tuberculosis drug used primarily to treat human patients with tuberculosis. Although isoniazid is effective and safe in humans, it can have toxic effects in dogs.

The reason isoniazid is considered toxic to dogs is because dogs lack enough enzymes (hepatic amidases) to metabolize and break down isoniazid effectively. This can cause isoniazid to accumulate in the dog's body and produce toxic effects at high doses.

When dogs ingest or are exposed to high concentrations of isoniazid, the following health problems may occur:

1. Nervous system toxicity: The accumulation of isoniazid in dogs may cause damage to the nervous system and cause central nervous system symptoms such as ataxia, convulsions, coma, etc.

2. Liver toxicity: Isoniazid can have a toxic effect on the dog’s liver, causing abnormal liver function.

3. Hematological toxicity: High doses of isoniazid may have adverse effects on the dog’s hematopoietic system, causing anemia or other blood-related problems.

Therefore, isoniazid is toxic to dogs and should not be used to treat dogs. If your dog requires medical attention, be sure to consult your veterinarian for appropriate treatment options and medications.

animal tags：